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Antipsychotic Effect of Aqueous Stem Bark Extract of Amblygonocarpus Andongensis in Wistar Albino Rats

By Animal Research International, University Of Nigeria, Nsukka.

Summary

ABSTRACT:
The study of antipsychotic ef ect of the aqueous stem bark extract of Amblygonocarpus andongensis was carried out on amphetamine induced psychosis in 42 Wister albino rats weighing between 105 and 305 2g using two indices feeding and locomotor activity. Twelve out of the 42 rats were divided into two groups; six per group. Group 1 and 2 received 1 5mg/kg body weight o oral amphetamine. Oral chlorpromazine (0.5mg/kg) was administered to group 2 rats in addit on The remaining 30 rats were divided in o 5 groups: A, B, C, D and E, each group comprised 6 rats. All the groups received 1 5 mg/kg body weight of amphetamine but E received 0 5mg/kg oral chlorpromazine in add t on. However, B, C and D received 450, 900 and 1350mg/kg bodywe ght of Amblygonocarpus andongensis aqueous stem bark extract. Feeding and locomotor activities were measured in groups 1 and 2 and A, B, C, D and E rats respectively. The result showed that there were significant dif erences in feeding and locomotor parameters between groups 1 and 2 and among groups A, B, C and E (p<0.05) except group E. In amphetamine psychotic model test, group 2 animals have reduced feeding and locomotor activity as compared to group 1. Conclusively, Amblygonocarpus andongensis has a dose dependent reducing effect on feeding and locomotor activity at 135mg/kg body we ght as compared to chlorpromazine (0.5mg/kg) in amphetamine induced psychosis in Wister albino rats. Hence i . i both Amblygonocarpus i f . and chlorpromazine may have pharmacokinetic effect on amphetamine and therefore maybe used to treat psychosis induced by amphetamine.
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